El intestino delgado, las incretinas y el metabolismo energético en la Diabetes mellitus

Cesar Ochoa

El intestino delgado, las incretinas y el metabolismo energético en la Diabetes mellitus

Cesar Ochoa

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Resumen

Las investigaciones completadas en años recientes han revelado el importante papel que juega el intestino delgado en la homeostasis energética del organismo por medio de las incretinas: enterohormonas que regulan el equilibrio entre las influencias de la insulina y el glucagon sobre el metabolismo glucídico, el vaciamiento gástrico, y el crecimiento y desarrollo de las células b presentes en los islotes pancreáticos. Las acciones biológicas de las incretinas han sido reconocidas en los sujetos en los que se ha observado remisión de la resistencia a la acción de la insulina tras la realización de cirugía bariátrica. El conocimiento íntimo de la biología y el efecto de las incretinas se ha traducido en nuevos enfoques terapéuticos y farmacológicos del tratamiento de la Diabetes mellitus.

Palabras clave

Intestino delgado; Incretinas; Insulina; Diabetes; Páncreas; Hígado

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